Another latest study suggests that differentiated GBM cells can be fully reprogrammed into tumor stem-like cells by induction of only four core transcription factors (TFs)—POU3F2, SOX2, SALL2, and OLIG2, further supporting the GSC plasticity and tumor hierarchy existing within GBM (Suvà et al., 2014). This evidence concerns the gene SOX2 and glioblastoma.