VEGFA and neoplasm: There are several types of regents to reduce tumor IFP in animal models and patients, such as anti-angiogenic drugs (VEGF inhibitors or PDGF inhibitors), TGF-beta inhibitors, Dexamethasone, Bradykinin agonists, Nicotinamide, and pro-inflammatory factor PGE1 (Heldin et al., 2004).