Heist et al. (2015) showed that combination of anti-VEGF and chemotherapy improved the overall survival and the tumor free period of patients with metastatic non-small lung cancer. Zhou et al. (2008) found that VEGFR inhibitor, sunitinib, enhanced tumor distribution of temozolomide due to vascular normalization and stability and reduction in IFP. However, Ribatti criticized that the vessel normalization followed by normalization of permeability may become the obstacle to chemotherapy (Ribatti, 2011). This evidence concerns the gene VEGFA and neoplasm.