Reduced expression of RACGAP1 gene responsible for metastasis Reduced tumor size of BNL hepatoma in mice (10 mg/kg oral administration) by expression of IFN-γ through ERK/MAPK signaling pathway; inhibited angiogenesis through CD4+T-cell-derived IFN-γInhibited the proliferation of A549 mediated through the increased p53 and p21 expression Acted as adjuvant with HPV-16 E7, increased lifespan of tumor-bearing mice through increased HPV-16 E7-specific antibodies and T cells. This evidence concerns the gene IFNG and hepatocellular carcinoma.