Induced proliferation of total murine splenocytes and only the T cells that is APC-dependent (co-cultured with irradiated splenocytes) (10–40 μg/mL)Resulted Th1-skewed immune response (prominent IFN-γ; littler or no IL-4 production in the supernatant) (10–40 μg/mL) Resulted increased serum IFN-γ in mice fed with 100–400 μg per mouse every day for 8 daysReduced systemic anaphylaxis-like symptom score and plasma histamine level in OVA challenged mice treated with FIP-fve. This evidence concerns the gene IL4 and anaphylaxis.