Nevertheless, his CRP concentration increased to 15.90 mg/dl, his erythrocyte sedimentation rate (ESR) was 51 mm/h (normal value <20 mm/h), and there was a further increase in his leukocytosis (WBC 22.30 × 103/μl) and neutrophilia (17.94 × 103/μl; 80.5%); his antistreptolysin O (ASO) titer was 451 UI/ml (normal value <200 UI). This evidence concerns the gene CRP and Increased total leukocyte count.