By this time, the patient’s obstructive jaundice symptoms were severe and disabling, and biochemical analysis revealed worsening cholestasis (total bilirubin 39 mg/dl, ALP 651 IU/L), relatively normal liver enzymes (AST 61 U/L, ALT 62 U/L, gamma-glutamyltransferase [GGT] 25 U/L] with normal liver function (serum albumin 3.7 g/dl, serum globulin 1.9 g/dl, INR 1.00, APTT 29 seconds), normal full blood count, normal inflammatory markers, and normal renal profile. This evidence concerns the gene GPT and cholestasis.