Due to the assessed transcriptome changes and upregulation of TGFB1 and TGFB2 itself, it is suggested that knockdown of ERβ resulted in activation of TGFβ1/2 signaling, which resulted in induction of genes with known functions in extracellular matrix and tumor cell invasion (Fig. 5). The gene discussed is TGFB1; the disease is neoplasm.