On the contrary, it has been observed that EHEC as wells as EPEC strains could suppress NF-κB and MAPK activation as well as IκB degradation, [13] and could inhibit the production of proinflammatory cytokines IL-8 and IL-6, early in the infection by different LEE- and non-LEE encoded effectors (Tir, NleB, NleC, NleD, NleE, NleH1 and NleH2) [14]. The gene discussed is CXCL8; the disease is infection.