For example, numerous growth factor receptors, such as type 1 insulin-like growth factor receptor (IGF-1R), mesenchymal-epithelial transition factor receptor (MET receptor), and the human epidermal growth factor receptor-2 (HER2) [86–88], can activate EGFR downstream effectors and trigger the ensuing intracellular signaling pathways by bypassing EGFR, thus inducing tumor cell proliferation and resistance to apoptosis (Figure 3). This evidence concerns the gene EGFR and neoplasm.