We collected nine KRAS or BRAF mutant CRC cell lines and inhibited the MEK/ERK pathway and/or the PI3K/AKT pathway downstream of RAS-RAF with a MEK inhibitor (MEKi) U0126 and/or an AKT inhibitor (AKTi) MK2206 [27, 28]. This evidence concerns the gene AKT1 and colorectal carcinoma.