PTEN and endometrial cancer: To investigate whether endometrial cancer cell functions are also influenced by PTEN expression status and if they are dependent upon p110α and/or p110β, we evaluated the cell viability of PTEN-positive (EM, KLE and MFE-280) and PTEN-deficient cell lines (MFE-319 and RL95-2) following treatment with the selective p110α (A66) and p110β (TGX-221) inhibitors (Figure 3A) [34].