SOX2 and head and neck squamous cell carcinoma: Finally, the analysis of the patients’ survival data showed a prognostic relevance for SEC62 and SOX2 in terms of a significantly longer overall survival when the SEC62 gene was expressed at a low level (p < 0.0001) and the SOX2 gene was expressed at a high level (p = 0.003) in the lymph node metastases of HNSCC and CUP patients (Figure 6).