SOX2 and head and neck squamous cell carcinoma: Taken together, these data indicate the stimulation of lymphatic metastasis in HNSCC and CUP patients by high SEC62 expression levels, although these correlation analyses did not reach a comparably high significance, as shown for SOX2. Consistent with these findings, we found stimulation of the migratory potential of UM-SCC1 cells when the SEC62 gene was overexpressed and an inhibition of cell migration following SEC62 silencing without any effect on cell proliferation (Figure 5).