SOX2 and cancer: 3q26 amplification represents a highly frequent chromosomal alteration in HNSCCs [11, 12] and encodes the genes SEC62 and SOX2, which have both been shown to be overexpressed in various cancers [13–15, 45], including HNSCCs [27, 35, 46], and to affect the metastatic potential of cancer cells [22, 23, 26, 37, 39–42, 44, 47].