SEC62 and head and neck squamous cell carcinoma: For SEC62, immunohistochemical analyses of the tissue specimens revealed a tendency towards higher expression levels in the lymph node metastases of HNSCC patients compared with their respective primary tumor (Figure 2C), a tendency towards higher expression in the lymph node metastases of CUP compared with HNSCC patients (Figure 3A) and a gradually increasing expression level from N1 to N3 cervical lymph node status (Figure 3B).