When comparing the SEC62- and SOX2-mIRS between the primary tumor and the metastases of the HNSCC patients, we found a weak tendency towards an elevated SEC62 expression (60% of cases; p = 0.221, Mann-Whitney-test) and a significantly lower SOX2 expression (91% of cases; p < 0.0001, Mann-Whitney-test) in the metastases compared with the primary tumor (Figure 2C, 2D). The gene discussed is SEC62; the disease is head and neck squamous cell carcinoma.