RdB/IL12/DCN-treated groups exhibited significantly higher IFN-γ and TNF-α than groups treated with PBS, RdB, RdB/IL12, or RdB/DCN (P < 0.001) (Figure 4C and 4D), suggesting that RdB/IL12/DCN induced a potent tumor-specific adaptive immune response. Here, DCN is linked to neoplasm.