Oncolytic Ad-mediated suppression of TGF-β expression in tumor tissues correlated with enhanced induction of antitumor immune responses as evidenced by enhanced infiltration of T cells into tumor tissue treated with RdB/IL12/DCN compared with a cognate control oncolytic Ad expressing a single therapeutic gene (RdB/DCN or RdB/IL12). The gene discussed is TGFB1; the disease is neoplasm.