DCN and neoplasm: In contrast, RdB/IL12/DCN-treated tumors continued to show tumor growth inhibition during later time periods, suggesting that oncolytic Ad-mediated expression of DCN functioned as an adjuvant to IL-12 and enhanced the antitumor efficacy of oncolytic Ad (P < 0.05, RdB/IL12/DCN versus RdB/IL12 by 17 days).