Parameter estimation forEq (12): The most common mutations in NSCLC occur in tumor suppressors TP53 and ALK, and in oncogenes PTEN, EGFR, KRAS, LKB1 and BRAF, and mutations seem to occur more frequently in MAPK (KRAS, BRAF) than in PI3K-AKT [21, 75, 76]. This evidence concerns the gene BRAF and non-small cell lung carcinoma.