In a multivariate analysis comparing between R018 and R017 infections, R018 infections caused a higher CRP level (1.04, 1.01–1.08, p = 0.021), less frequent hypoalbuminemia (0.41, 0.2–0.84, p = 0.014), but more frequent severe CDI assessed by leukocytosis and azotemia (1.88, 1.05–3.37, p = 0.034). The gene discussed is CRP; the disease is clostridium difficile infection.