LGMN and cancer: This is supported by the finding of i) Lower levels of the tumor-associated protease, legumain, in intestines of the AndosanTM treated A/J Min/+ mice, ii) Higher serum levels of Th1 type cytokine, IL-12p70 in the treated A/J Min/+ and wild-type mice, and iii) Strong, dose-dependent cytotoxic effect induced in vitro by AndosanTM on the human cancer colon cell line, Caco-2.