Currently, the process of liver fibrosis, cirrhosis, and development to HCC have achieved some consensus, and it is clear that chronic HBV infection is the most important factor in HCC development.[14–16] In China, the vast majority (about 95%) of HCC patients have HBV infection and liver cirrhosis, and patients with liver cirrhosis, portal hypertension, hypersplenism, and low platelet and WBC levels develop HCC; on the other hand, due to liver damage, serum liver biochemistry enzyme indexes are increased—for example, ALP, AST, ALT, and γ-GT levels—primarily leading to an increased APPRI. The gene discussed is GPT; the disease is portal hypertension.