CRP and congenital rubella syndrome: No immediate infusion-related toxic effect was noted, but she developed a febrile syndrome, with rigor and transient hypotension by days +5 to +8, cytokine levels (Fig. 1A), C-reactive protein (CRP 161.3 mg/L), and ferritin (139,355.4 ng/mL) increased significantly, anti-infection treatment was ineffective, indicating Grade 2 cytokine release syndrome (CRS) according to the University of Pennsylvania grading system.