VEGFA and glaucoma: Meanwhile, patients with pre-existing glaucoma were more vulnerable to anti-VEGF; indeed, a RR of 2.6 (CI 1.16–5.81, P = 0.02) was obtained for studies excluding pre-existing glaucoma, while 3.48 (CI 1.38–8.78, P = 0.008) was found in those including patients with pre-existing glaucoma.