GCKR and Crohn disease: The missense variant rs1260326 (hg19 chr2:g.27730940T>C; in GCKR) is associated with all three traits, and genome-wide significant for FG,16 2G,17 blood metabolite levels, cardiovascular disease risk factors, metabolic and lipid traits, gout, liver enzyme levels, and chronic kidney disease.15 Additional variants within GCKR are genome-wide significant for FI-related traits16 and Crohn's disease.