The SNP rs7903146 acts as a positive control, since it is the lead SNP in TCF7L2 for associations with T2D,18 FI-related traits (interaction with BMI),5 and FG-related traits (interaction with BMI)5 and is also genome-wide significant for 2G16 and FG;16 this SNP is also our top signal for the FI-2G overlap and for each of FG and 2G. This evidence concerns the gene TCF7L2 and type 2 diabetes mellitus.