ADCY5 and type 2 diabetes mellitus: A further positive control is detection of the FG-2G variant rs11708067 (in ADCY5), which is known to be associated with FG16 and is in LD with a known 2G-associated SNP rs2877716 (r2=0.807).17 Each FI-2G variant that is regulatory in a metabolism-involved tissue is within a gene containing FI- or T2D-associated variants (P<5 × 10−6).