INS and type 2 diabetes mellitus: An additional missense variant rs13266634 (hg19 chr8:g.117172544C>T; in SLC30A8) is associated with both FG and 2G, and genome-wide significant for T2D,18 FG,16 fasting proinsulin levels,19 and glycated haemoglobin levels.20 These results are positive controls, since the variants were known to be genome-wide significant for the traits and our method both detects this overlap and suggests that these numbers are greater than expected by chance.