Several hub genes in this module showed a strong differential expression between AD and water-treated mice, including the calcium dependent cell–cell adhesion molecule, Cdh7 (FC = 0.44, p = 7.28 × 10−04); a member of a family with sequence similarity 3 (FAM3), Fam3c (FC = 0.23, p = 3.5 × 10−03); and a gene encoding a protein that promotes adhesion between dendrites and axons, Nxph1 (FC = 0.23, p = 4.75 × 10−03). This evidence concerns the gene FAM3C and Alzheimer disease.