TGFB1 and neoplasm: M2-like TAM are alternatively activated and produce anti-inflammatory cytokines like IL-4, IL-10, IL-13, transforming growth factor-b (TGF-b), and various chemokines to turn off damaging immune system activation and get involved in proliferation and survival of leukemia stem cell (LSCs), progression and metastasis, facilitating angiogenesis and lymphangiogenesis, matrix remodeling, and tumor cell-motility [30, 31].