In another functional aspect, calcium ionophore/phorbol ester induces terminal maturation of MOLT-4 T cell acute lymphoblastic leukemia, which is due to Ser14 phosphorylation of WWOX, IκBα–ERK–WWOX signaling, and expression of CD3 and CD8 (Lin et al., 2011; Huang et al., 2016). This evidence concerns the gene WWOX and acute lymphoblastic leukemia.