For example, tumor suppressor WWOX is frequently missing in cancer cells (Bednarek et al., 2000; Chang et al., 2001, 2003, 2007; Iliopoulos et al., 2005; Aqeilan and Croce, 2007; Chiang et al., 2013; Gardenswartz and Aqeilan, 2014; Abu-Remaileh et al., 2015; Schrock and Huebner, 2015; Huang et al., 2016). This evidence concerns the gene WWOX and neoplasm.