WWOX and Other metabolic disease: Notably, null mutations of WWOX/Wwox gene in humans and animals lead to severe neural diseases (e.g., microcephaly, seizure, ataxia, etc.), growth retardation, metabolic disorders, developmental delay, and early death (Aldaz et al., 2014; Chang et al., 2014; Alkhateeb et al., 2016; Elsaadany et al., 2016).