Human WWOX gene has 1.1 million bases and is located on a chromosomal common fragile site 16q23 or FRA16D. High frequency of loss of heterozygosity (LOH) of WWOX gene at approximately 30–50% levels has been shown in many types of cancer cells (Aqeilan and Croce, 2007; Chang et al., 2007; Del Mare et al., 2009; Gardenswartz and Aqeilan, 2014; Abu-Remaileh et al., 2015; Chang, 2015; Chang et al., 2015; Richards et al., 2015; Schrock and Huebner, 2015). The gene discussed is WWOX; the disease is cancer.