Hughes et al. [29] and his colleagues identified that UCA1 is a novel target of both C/EBPα isoforms, i.e. C/EBPα-p42 and C/EBPα-p30, and the short isoform C/EBPα-p30 induces the expression of UCA1, leading to the abnormal up-regulation of UCA1 in CEBPA-mutated AML patients [29]. The gene discussed is CEBPA; the disease is acute myeloid leukemia.