Diabetes can produce long-term negative effects, such as high blood glucose, hypoglycemia, free radical-mediated oxidative stress, brain blood vessel reconstruction disorder and abnormal brain insulin [30, 31], thus, diabetes may represent a metabolic state in which neuroprotective and neuromodulatory effects of insulin in the Central Nervous System were disrupted [32], and causes brain damage. Here, INS is linked to Hypoglycemia.