In the present study, we investigated the correlation between serum IL-17/ IL-10 concentrations and osteoporosis in context with1, 25-dihydroxyvitamin D3, Ca2+/Pi ions and parathormone in old people who have already participated in the cohort project named Amirkola Health and Ageing Project(AHAP) cohort. The gene discussed is IL10; the disease is osteoporosis.