The logistic regression with stepwise selection by BIC found that the ratio of Hmox1/Nrf2 mRNA by percentage in the tumor tissue (odds ratio: 0.83; 95% confidence interval: 0.68–0.97) and CEA (1.0027; 1.006–1.064) were predictors for distant metastasis in CRC. This evidence concerns the gene NFE2L2 and neoplasm.