NPC2 and nasopharyngeal carcinoma: The beneficial effects of HPβCD in NPC models remains unclear and have been studied in macrophages in which HPβCD exhibits its cholesterol extraction capacity for relatively high concentration of the CD (from >10 mM to 100 mM), whereas at much lower concentration (<1 mM) HPβCD rather behaves as a cholesterol transferring system between membranes of the LE/LY compartment [54,65], in a similar manner to NPC2 function [110].