To investigate whether changes in complex formation between human procarboxypeptidases and proelastases alter risk for CP, we investigated the frequency of variants c.722G>C (p.G241A) in CELA3A and c.722C>G (p.A241G) in CELA3B in subjects with CP and controls without pancreatic disease. The gene discussed is CELA3A; the disease is pancreas disorder.