Activation or over expression of the P2X7 receptor has also been implicated in damage to motor neurons [102], and blockage of the P2X7 receptor by ATP has shown a neuroprotective effect in animal models of multiple sclerosis [103], Huntington’s disease [104] and in Alzheimer’s disease [105]. This evidence concerns the gene P2RX7 and early-onset autosomal dominant Alzheimer disease.