In this respect, it should be noted that systemic metabolic derangements such as hyperglycemia and dyslipidemia are similar in most models of type 1 and type 2 diabetes, thus pointing towards differences in myocardial insulin action (insulin resistance with accompanying hyperinsulinemia versus insulin deficiency) as an underling factor that may explain phenotypic differences between the distinct types of diabetes. This evidence concerns the gene INS and diabetes mellitus.