As shown by others, a reduced expression of GLO1 using shRNA led to a significant inhibition of cell growth and induction of apoptosis in primary cultured cells from hepatocellular carcinoma (HCC) with an amplified GLO1 gene, whereas no inhibitory effect on cell proliferation was observed in HCC cells with normal GLO1 gene copy numbers [37,38]. The gene discussed is GLO1; the disease is hepatocellular carcinoma.