Another well-studied disease that arises from mutations on ADAR1 is dyschromatosis symmetrica hereditaria (DSH), a mild genodermatosis that results in phenotypes like hyper-pigmented and hypo-pigmented macules on the dorsal parts of one′s hands and feet, as well as freckle-like macules on the faces of infants and young children from Japan and China [34]. This evidence concerns the gene ADAR and dyschromatosis symmetrica hereditaria.