Studies from many groups have demonstrated the presence of many autoantibodies in whole saliva collected from pSS patients, including IgA and IgM rheumatoid factor, anti-Ro/SSA, anti-La/SSB, anti-spectrin, anti-Ro52, anti-Ro60, anti-transglutaminase, and muscarinic acetylcholine receptor (mAChR) IgA [45,47,48,49,50,51]. Here, CALR is linked to peeling skin syndrome.