Previous research has shown that biotransformation of blueberry juice by Serratia vaccinii increases its polyphenolic content and reduces lung metastasis of mammary carcinoma through influencing cellular signaling cascades of breast cancer stem cells, controlling PI3K/AKT, MAPK/ERK, and STAT3 pathways in mammary cancer stem cell inflammatory signaling [72]. This evidence concerns the gene AKT1 and breast cancer.