In support of the beneficial effects VOO phenolics exert on atherosclerosis risk factors, Konstantinidou and colleagues [76] reported that VOO containing 328 mg/kg compared to 55 mg/kg of phenolics down-regulates inflammatory genes Rho-GTPase-activating protein 15, interferon gamma and interleukin 7 receptor and also adrenergic beta 2 receptor and polymerase kappa; these are all implicated in atherosclerosis. The gene discussed is IFNG; the disease is atherosclerosis.