AHR and immune system disorder: While the molecular mechanisms underlying the regulation of CYP450 enzymes by Se-PFPs is not clear at present, it is known that aryl hydrocarbon receptor (AhR), the key transcriptional factors, is involved in transcriptional regulation of CYP450 genes, and the interactions between AhR and inflammatory signaling evidently can play a significant role in immune dysfunctions, metabolism of xenobiotics or carcinogenesis [39].