ABHD5 and obesity due to melanocortin 4 receptor deficiency: In HFD-induced mice, CGI-58 deficiency aggravated macrophage inflammation [50], but Knockdown of CGI-58 was found to prevent HFD-induced obesity and reduce the expression of both lipolytic and lipogenic genes in WAT [51], indicating that the role of CGI-58 for obesity under HFD is still controversial.