Previous reports have revealed that ELMO1 and -2 are aberrantly expressed in a variety of human malignant tumors including primary gliomas [16,17], breast cancer [18], liver cancer [19], ovarian cancer [20,21], esophageal cancer [22] and rhabdomyosarcoma [23], and are closely related to the development, invasion and metastasis of tumors and play key roles in related signal regulating processes [16,20,24,25,26,27,28,29]. This evidence concerns the gene ELMO1 and cancer.