LRP4 and autoimmune disease: Thymomas are associated with a wide variety of autoimmune diseases, and among these about 30%–40% of thymomas are associated with myasthenia gravis (MG), an autoimmune disease characterized by autoantibodies directed to different targets at the neuromuscular junction, such as acetylcholine receptor (AChR), muscle specific kinase (MuSK), and agrin-receptor low-density lipoprotein receptor related-protein 4 (LRP4) [3].