According to the network parameters, the importance of targets and herbs in treatment of MS by WDD were identified in order: PPARγ > LXRα > PPARα > LXRβ > PPARβ > RXRα and Radix Glycyrrhizae Preparata > PoriaCocos > Citrus Aurantium > Pericarpium Citri Reticulatae > Pinellia Ternate, respectively. The gene discussed is NR1H3; the disease is myeloid sarcoma.