Studies of PI3K inhibition in a KRASmut/PIK3CAWT CRC model demonstrated that due to MAPK activation PI3K inhibition alone was insufficient in inducing anti-proliferative effects, thereby alluding to the significance of the RAF/MAPK pathway in the proliferation of KRASmut/PIK3CAWT CRC [50]. The gene discussed is RAF1; the disease is colorectal carcinoma.