Although not an ERK1/2 mediated phosphorylation event, a decrease in the phosphorylation of ribosomal protein S6 (“S6”) at residues S240/244 is implicated in the responsiveness to selective BRAF inhibition in BRAFmut melanoma cells [25], therefore we examined the effects of LY3009120 on this phosphorylation event in CRC. The gene discussed is RPS6; the disease is melanoma.