Consistent with the involvement of the RAS/RAF/MEK/ERK signaling cascade in cell cycle progression [30] and previous studies of LY3009120 in melanoma [15], the anti-proliferative effects of LY3009120 in CRC were associated with G1 cell cycle arrest and isolated induction of cell death in both BRAFmut and KRASmut CRC cell lines. Here, MAPK1 is linked to melanoma.