RAF1 and neoplasm: Various genetic and signaling factors contribute to the progression of colon cancer, including microsatellite instability (MSI), mutational inactivation of tumor-suppressor genes such as APC, TP53 and TGF-β, as well as aberrant activation of pro-survival pathways such as the RAS/RAF/MEK/ERK and PI3K/mTOR pathways [1].