MAPK1 and colorectal carcinoma: Consistent with the involvement of the RAS/RAF/MEK/ERK signaling cascade in cell cycle progression [30] and previous studies of LY3009120 in melanoma [15], the anti-proliferative effects of LY3009120 in CRC were associated with G1 cell cycle arrest and isolated induction of cell death in both BRAFmut and KRASmut CRC cell lines.