In the examination of the relative low and high S4S8-RPA phosphorylation groups to tumor stage, all 8 of the high S4S8-RPA phosphorylation tumors in this study were early stage, T1-T2 tumors, compared to the low S4S8-RPA phosphorylation group which had close to half of the samples as late stage (T3-T4) tumors. The gene discussed is RPA1; the disease is neoplasm.