The interactions between GSK-3, PI3K/PTEN/Akt/mTORC1, Ras/Raf/MEK/ERK, Wnt/beta-catenin, Hh, Notch and TP53 pathways are clearly having important roles in regulating EMT and CSCs and some of the components may serve as prognostic indicators for various cancer. Here, PIK3CA is linked to cancer.