PTEN and cancer: The interactions between GSK-3, PI3K/PTEN/Akt/mTORC1, Ras/Raf/MEK/ERK, Wnt/beta-catenin, Hh, Notch and TP53 pathways are clearly having important roles in regulating EMT and CSCs and some of the components may serve as prognostic indicators for various cancer.