The chemokine (C-X-C Motif) Receptor 2/chemokine (C-X-C Motif) Ligand 5 (CXCR2/CXCL5) interaction have been shown to regulate the PI3K/PTEN/Akt/mTORC1/GSK-3-beta/Snail pathway in HCC. The gene discussed is CXCL5; the disease is hepatocellular carcinoma.