MAPK3 and neoplasm: Similar results were showed in present in 10μM U0126 which could inhibit phosphorylation of ERK1/2, the phosphorylation of ERK1/2 of different clones were also indistinctive, the overexpression of SPINK6 could not reduce the phosphorylation of ERK1/2 more, so the tumor suppression function of SPINK6 seemed to be also largely blocked, although minor inhibition of the tumorigenic phenotypes could be still detected (Supplementary Figure S4).