Similar results were showed in present in 10μM U0126 which could inhibit phosphorylation of ERK1/2, the phosphorylation of ERK1/2 of different clones were also indistinctive, the overexpression of SPINK6 could not reduce the phosphorylation of ERK1/2 more, so the tumor suppression function of SPINK6 seemed to be also largely blocked, although minor inhibition of the tumorigenic phenotypes could be still detected (Supplementary Figure S4). Here, SPINK6 is linked to neoplasm.