In contrast, growth arrest-specific 5 (GAS5) is down regulated in breast cancer and hepatocellular carcinoma [20, 21], and maternally expressed 3 (MEG3) is downregulation in meningioma and colorectal cancer [22, 23], indicating that these two lncRNAs are involved in tumor suppression. Here, MEG3 is linked to hepatocellular carcinoma.