PDAC cells released exosmes in an integrin-b4 dependent manner. Integrin-b4 in exosomes, led to mislocalisation of plectin to the cell surface. Plectin was also found to enhance growth of the tumour in immunocompromised mice. Additionally, plectin was found to be key in the secretion of exosomes and contributed to the tumorigenic properties of exosomes. Here, PLEC is linked to neoplasm.