Although some p53 induction was observed in K562 cells treated with JNJ-165, PFTα, an inhibitor of p53, did not prevent JNJ-165-mediated cell death, suggesting that cell death induced by JNJ-165 is independent of the MDM2-p53 interaction in human CML cells. The gene discussed is MDM2; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.