In addition, the small molecular deubiquitinase inhibitor WP1130 and histone deacetylase inhibitor LAQ824 were also found to induce BCR/ABL ubiquitination, which results in a reduction in BCR/ABL signaling and promotes CML cell apoptosis [38, 39]. This evidence concerns the gene BCR and chronic myelogenous leukemia, BCR-ABL1 positive.