This up-regulation of NHERF1 was rapid for hypoxia (within 30 min) (Figure 2A, 2C) suggesting that NHERF1 could serve as a rapid response element to the tumor hypoxia microenvironment and might contribute to the regulation to the VEGF/VEGFR signaling pathway in driving metastatic progression. The gene discussed is NHERF1; the disease is neoplasm.