It was also reported that expression of NHERF1 was strongly correlated with expression of HIF1α and VEGFRs both in breast cancer and lymphatic metastastic colorectal cancer [30, 31], indicating that NHERF1 expression might be involved in metastatic progression by regulating the cell adaptive changes to the tumor microenvironment. The gene discussed is NHERF1; the disease is breast cancer.