Saphner et al [22] wisely stated that “perhaps the long-term recurrence rate for ER-positive and ER-negative patients will be the same but with the ER-negative recurrences occurring more frequently in early follow-up and the ER-positive recurrences occurring in late follow-up.” In consistent with this statement, our present study demonstrated that the 10-year DFS for Luminal B, TNBC and HER2 breast cancers were similar, TNBC and HER2 breast cancer recurrences occurring more frequently in early follow-up and Luminal B recurrences occurred both in early and late follow-up. The gene discussed is ERBB2; the disease is breast cancer.