When the analysis was stratified by breast cancer subtypes, as shown in Figure 4A–4D, we found that Luminal A was statistically significantly associated with better DFS when compared with the other subtypes, and TNBC and HER2 subtypes had worse survival outcome over the first five years after surgery in pN0-pN2 stage (all P < 0.05). The gene discussed is ERBB2; the disease is breast carcinoma.