Tumors treated with BGJ398 slowed or reversed their growth compared with vehicle (Figure 2C, upper panel), so that by the end of the study, the effect on tumor burden in vehicle-treated versus BGJ398-treated mice were 3.3-folds in FGFR3 (S249C), three-fold in FGFR3 (G691R) and 2.25-fold in FGFR3-WT xenografts (Figure 2D). This evidence concerns the gene FGFR3 and neoplasm.