We present the first portrait of clinically actionable alterations in lung adenocarcinoma of Indian origin that includes EGFR, KRAS, EML4-ALK, AKT1, PIK3CA, FGFR4 and ERBB2, similar to that identified in other ethnic groups [5, 22, 23], and an additional subset of patients with FGFR3 mutations. This evidence concerns the gene PIK3CA and lung adenocarcinoma.