HLA-DRB1 and juvenile idiopathic arthritis: The most significant association in sJIA was for HLA-DRB1*11, consistent with recent findings from a large genome-wide association study for sJIA, which used an overlapping set of samples.17 Previous studies of a HLA association with sJIA had yielded conflicting results, but there is now clear evidence for association of the HLA region with this category of JIA.